ISSN 1662-4009 (online)

ey0015.1-5 | New mechanisms | ESPEYB15

1.5 NOTCH activity differentially affects alternative cell fate acquisition and maintenance

L Cheung , P Le Tissier , SG Goldsmith , M Treier , R Lovell-Badge , K Rizzoti

To read the full abstract: Elife 2018;7. pii: e33318Here, Cheung et al. use sophisticated tissue specific genetic ablation in pituitary cell lineages to uncover an unexpected differential sensitivity of NOTCH activation signalling pathway in different cell lineages during the embryonic murine pituitary development. These findings are important as they further demonstrate the importance of NOTCH pat...